We compared vaccination status of 2880 people with non-influenza respiratory viruses to 3240 people with pan-negative results. Comparing accinated to non-vaccinated patients, the adjusted odds ratio for non-flu viruses was 0.97 (95% confidence interval (CI): 0.86, 1.09; p = 0.60). Additionally, the vaccination status of 3349 cases of influenza were compared to three different control groups: all controls (N = 6120), non-influenza positive controls (N = 2880), and pan-negative controls (N = 3240). The adjusted ORs for the comparisons among the three control groups did not vary much (range: 0.46–0.51).
And:
Receipt of influenza vaccination was not associated with virus interference among our population. Examining virus interference by specific respiratory viruses showed mixed results. Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus; however, significant protection with vaccination was associated not only with most influenza viruses, but also parainfluenza, RSV, and non-influenza virus coinfections.
Let me repeat that: Receipt of influenza vaccination was not associated with virus interference among our population. In other words, this is a negative study. The authors did not observe viral interference.
Then, in the conclusion:
The overall results of the study showed little to no evidence supporting the association of virus interference and influenza vaccination. Individual respiratory virus results were mixed, and some rebutted virus interference.
I also note that the odds ratio of having coronavirus in those vaccinated against the flu compared to those who were not was only 1.36 (95% confidence interval 1.14-1.63). That’s not very impressive at all.
Here’s what we’re probably seeing: Noise. With the odds ratio of influenza virus significantly decreased (the odds ratios range from 0.39 to 0.88, depending on the specific influenza strain), the rest of the various viruses detected fluctuated around an odds ratio of 1.0 (no difference). Indeed, most of the non-influenza viruses tested for (6/8) demonstrated odds ratios lower than 1.0 (range: 0.67-1.51). Only coronavirus and human metapneumovirus showed odds ratios of more than 1.0 (1.36 and 1.51, respectively), with the rest all lower than 1.0. Moreover, the odds ratio of having no pathogen detected in the group receiving the flu vaccine was 1.59 (95% CI 1.44-1.75), meaning that those who had the flu vaccine were 59% more likely not to have any respiratory virus detectable at all.
I love it when an antivaxxer cites a negative study to support a claim. It smells like…cluelessness.
I also love the inconsistency of this new trope. After all, what is it that antivaxxers keep claiming year after year? It’s that the flu vaccine doesn’t work. Yet removal of virus interference by the flu vaccine couldn’t cause increased susceptibility to other respiratory viruses unless the flu vaccine were effective and reduced the chance of infection with the influenza virus. (I know, I know. Consistency was never a thing among antivaxxers.)
Fake News:
Let’s go to the findings:
We compared vaccination status of 2880 people with non-influenza respiratory viruses to 3240 people with pan-negative results. Comparing accinated to non-vaccinated patients, the adjusted odds ratio for non-flu viruses was 0.97 (95% confidence interval (CI): 0.86, 1.09; p = 0.60). Additionally, the vaccination status of 3349 cases of influenza were compared to three different control groups: all controls (N = 6120), non-influenza positive controls (N = 2880), and pan-negative controls (N = 3240). The adjusted ORs for the comparisons among the three control groups did not vary much (range: 0.46–0.51).
And:
Receipt of influenza vaccination was not associated with virus interference among our population. Examining virus interference by specific respiratory viruses showed mixed results. Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus; however, significant protection with vaccination was associated not only with most influenza viruses, but also parainfluenza, RSV, and non-influenza virus coinfections.
Let me repeat that: Receipt of influenza vaccination was not associated with virus interference among our population. In other words, this is a negative study. The authors did not observe viral interference.
Then, in the conclusion:
The overall results of the study showed little to no evidence supporting the association of virus interference and influenza vaccination. Individual respiratory virus results were mixed, and some rebutted virus interference.
https://respectfulinsolence.com/2020/03/31/coronavirus-viral-interference/
"Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus."
I also note that the odds ratio of having coronavirus in those vaccinated against the flu compared to those who were not was only 1.36 (95% confidence interval 1.14-1.63). That’s not very impressive at all.
Here’s what we’re probably seeing: Noise. With the odds ratio of influenza virus significantly decreased (the odds ratios range from 0.39 to 0.88, depending on the specific influenza strain), the rest of the various viruses detected fluctuated around an odds ratio of 1.0 (no difference). Indeed, most of the non-influenza viruses tested for (6/8) demonstrated odds ratios lower than 1.0 (range: 0.67-1.51). Only coronavirus and human metapneumovirus showed odds ratios of more than 1.0 (1.36 and 1.51, respectively), with the rest all lower than 1.0. Moreover, the odds ratio of having no pathogen detected in the group receiving the flu vaccine was 1.59 (95% CI 1.44-1.75), meaning that those who had the flu vaccine were 59% more likely not to have any respiratory virus detectable at all.
I love it when an antivaxxer cites a negative study to support a claim. It smells like…cluelessness.
I also love the inconsistency of this new trope. After all, what is it that antivaxxers keep claiming year after year? It’s that the flu vaccine doesn’t work. Yet removal of virus interference by the flu vaccine couldn’t cause increased susceptibility to other respiratory viruses unless the flu vaccine were effective and reduced the chance of infection with the influenza virus. (I know, I know. Consistency was never a thing among antivaxxers.)
https://respectfulinsolence.com/2020/01/30/coronavirus-flu-vaccine/
thank you very much for the interesting information, good luck to you