Cholestasis in Pregnancy:
• It 2nd most common cause of jaundice in pregnancy(m/c being hepatitis in pregnancy) • It is characterized by accumulation of bile acids in liver.
Clinical Features: •
Manifestation appears beyond 30 weeks (i:e in 3rd trimester) and occasionally in late 2nd trimester. •1st symptom to appear is pruritis-which has a predilection for the palms and soles. (pruritis appears 3 weeks before lab findings) • Jaundice is sligh-t bilirubin levels rarely exceed 5mg. • Recurs in subsequent pregnancies and so OCP’s are contraindicated in females with H/O cholestasis during pregnancy. • M/c in twin pregnancy.
[Source](https://books.google.com.np/books?id=WiPxAwAAQBAJ&pg=PA87&lpg=PA87&dq=Manifestation+appears+beyond+30+weeks+(i:e+in+3rd+trimester)+and+occasionally+in+late+2nd+trimester.+%E2%80%A21st+symptom+to+appear+is+pruritis-which+has+a+predilection+for+the+palms+and+soles.+(pruritis+appears+3+weeks+before&source=bl&ots=ipXp5JtkIp&sig=ACfU3U1CM5vKWAtA_7avP9i6k8m-KdaopA&hl=en&sa=X&ved=2ahUKEwiE49mq3s7qAhXZAnIKHZLZClEQ6AEwCnoECAoQAQ#v=onepage&q=Manifestation%20appears%20beyond%2030%20weeks%20(i%3Ae%20in%203rd%20trimester)%20and%20occasionally%20in%20late%202nd%20trimester.%20%E2%80%A21st%20symptom%20to%20appear%20is%20pruritis-which%20has%20a%20predilection%20for%20the%20palms%20and%20soles.%20(pruritis%20appears%203%20weeks%20before&f=false)
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