The darkest aspect of these questions is not the questions, but the answers.
Yes, the correct answer. Not the answer that results in debate, but the answer that results in action. Nothing could be more dark.
But what is this action? Does it need to be said? Planned? Plotted? Executed?
Do we begin today; do we petition a government? Do we try to get this idea popular, or keep it quiet? Do we brainwash high-mutation load people and convince them it's horrid and wrong to breed? Do we go to war to justify this sort of thing? No one would want to be the one NOT in control of this system because then you're at risk for being Deselected from the gene pool, by humans hands, rather than the hands of nature.
Yet, if nature's hands have been forcefully amputated by human hands, then what choice do we have? There's no room here for denial. And there's no reason to think a solution will magically appear.
Instead of asking questions, it might be best to begin directly stating the answer, and leave no room for anyone else's answer. Don't ask "What should we do?" Instead ask, "Who will help me do it?" And of course, define exactly what must be done.
If this is your pet project, then start getting this legally defined and initiated. Look at the old laws that enabled this sort of thing, and look at what laws nullified it. Find the solution to these hurdles and face naysayers with rock-solid justification.
Sometimes being laconic is best: The weak must perish so that the strong survive. Else the world will fall.
Elective, consumer level CRISPR is the answer. People will not only choose it, and choose what changes to make, they will pay for the opportunity. This solves all issues relating to government intrusion on our rights, individual consent, and so on. Nobody is "deselected", nobody is sterilized, nobody dies, except the natural process by which future generations will replace us either way. This way, we have the choice to make those future generations healthier and smarter than the generations before them, rather than the reverse.