Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron CrystallographyDaniel W. Kneller
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00058
Protonation states in SARS-CoV-2 main protease mapped by neutron crystallography
https://pubmed.ncbi.nlm.nih.gov/33060199/
Overview of antiviral drug candidates targeting coronaviral 3C‐like main proteases
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https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15696
Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage
https://www.nature.com/articles/s41586-019-1257-5
CRISPR Enzyme Protects Bacteria by Turning Infected Cells on Themselves
https://www.hhmi.org/news/crispr-enzyme-protects-bacteria-turning-infected-cells-themselves
3CL Mpro; 3CL main protease; SARS–CoV-2; SARS–CoV-2 3CL main protease; X-ray crystallography; drug design; enzyme mechanism; hydrogen bond; joint neutron; neutron diffraction; protonation state; room temperature; viral protease.
Acid-Base Catalysis
https://www.sciencedirect.com/topics/materials-science/acid-base-catalysis
https://www.creative-enzymes.com/resource/Acidbase-Catalysis_40.html
Acid-Base Catalysis
In enzyme-mediated catalysis, general acid-base catalysis occurs when an acidic or basic residue at the active site is used to facilitate proton transfers in the reaction. As an example of general acid-base (and covalent) catalysis.
Double Displacement Reactions (Salt Metathesis)
Double displacement reactions are also known as salt metathesis reactions or double replacement reactions. Like any other chemical reaction, these chemical reactions also involve the conversion of certain chemical compounds (ionic or covalent) into a new chemical compound.
Enolization
https://en.m.wikipedia.org/wiki/Enol
Zwitterion
https://en.m.wikipedia.org/wiki/Zwitterion
Chemiosmosis
https://en.m.wikipedia.org/wiki/Chemiosmosis
Acid-Base Catalysis
