Best answer so far. Anime is the best when it comes to asking this kind of questions. I have a very good feeling Death Stranding by Hideo Kojima would really push things from the gaming side of things. Here is an article I wrote about it. GitS live action destroyed everything that made the franchise what it is and completely destroyed the character of Motoko. Even the recent "GitS:Arise" managed to remain mostly GitS due to the subject material and the complex stories it told.
There are some great obscure anime like Boogiepop Phantom and Serial Experiments Lain and Neon Genesis Evangelion is another absolute masterpiece. Even the new Godzilla anime trilogy chose focus on these existential side (sacrificing monster action and enraging most "fans") and Shin Godzilla was really great too.
Spoilers!!!