Oh Tom Hanks! I have seen so many movies but Castaway has been one of the ones coming to mind first. I really really loved how he took on that role on the deserted island with Mr Wilson :) I think everyone that saw that movie remembers that part, while many other movies are not remembered forever. Another one that stands out from him (imo) is The Terminal, great acting here too!
Will check the entries from the community for sure, would love to read what others they come up with (that I probably forgot lol)