Personally I think Quix works really well as it allows a speed debuf to combine with other cards that affect speed and miss chance plus the choice of any other available color. It opens up a lot of options for speed play and many different strategies depending on color combination.
Could even have other cards debuf melee/magic to just knock the enemy team down a notch across the board. Just recently acquired quix and a decent level Thaddius and it's impressive. Death and dragon were literally the ones I would reroll haha