I've never had a round ignite outside the chamber but it wouldn't be a lot of fun I'd say and would do a lot of damage to a human being if close enough. I've seen guns destroyed through malfunctions and rounds going off when they shouldn't and it's messy so a human would fare much worse I'd say.
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I wasn't even considering the fact of a gun blowing up but I guess that's some chain reaction possibility.
It happens and a little time on YouTube will show the results of such happenings. Of course they don't show those with hands blown off and faces missing although that happens too.