What plant has demonstrated as much as weed when it comes to health and wellness, and has also no harmful side effects and can't be overdosed? And how many such plants have been used for health and wellness for as long as weed has, and as widespread as weed? And finally, is there any other plant which can even produce any of the hundreds of cannabinoid compounds which interact directly with vertebrate endocanabinoid system?
The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors (CBRs), and cannabinoid receptor proteins that are expressed throughout the vertebrate central nervous system (including the brain) and peripheral nervous system.[1][2] The endocannabinoid system remains under preliminary research, but may be involved in regulating physiological and cognitive processes, including fertility,[3] pregnancy,[4] pre- and postnatal development,[5][6][7] various activity of immune system,[8] appetite, pain-sensation, mood, and memory, and in mediating the pharmacological effects of cannabis.[9][10] The ECS plays an important role in multiple aspects of neural functions, including the control of movement and motor coordination, learning and memory, emotion and motivation, addictive-like behavior and pain modulation, among others.[11]
Two primary cannabinoid receptors have been identified: CB1, first cloned in 1990; and CB2, cloned in 1993. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endogenous partial agonist, anandamide (AEA), as well as exogenous THC, the most known active component of cannabis. Endocannabinoid 2-arachidonoylglycerol (2-AG), which was found to be two and three orders of magnitude more abundant in mammalian brain than AEA, acts as a full agonist at both CB receptors.[12] Cannabidiol (CBD) is a phytocannabinoid that acts as a rather weak antagonist at both CBRs and a more potent agonist at TRPV1 and antagonist at TRPM8.[13] It is also known to be a negative allosteric modulator at CB1.[14] CBD has been found to counteract some of the negative side effects of THC.[15]
There are absolutely no plants, trees or any fauna that can hold a candle to the industrious plant that can literally clean radioactive waste out of the ground and no plant, tree, weed, shrub exists that can grow in such an extreme variety of terrains and utterly-devoid-of-life-and-nutrients soil as weed can. Finally, is there any plant which can produce anything close to the wide ranging terpen profile of weed, being able to recreate just about any smell in nature, some of which are exclusive to weed, like the sulfur producing type?