Part 4/10:
One of the most significant insights from animal and human studies is that 80% of our genes follow a 24-hour rhythm, governed by clock genes. When the timing of food intake aligns with these circadian patterns, organ health—especially liver function—improves markedly. Mice fed high-fat diets ad libitum (freely) gained weight and developed health issues, whereas those restricted to a feeding window of about 8 hours maintained better metabolic health and even reversed some negative effects. This suggests that timing of meals dramatically influences gene expression and overall health.
Optimal Timing and Duration of Fasting
Huberman advocates for an 8-hour feeding window, roughly from late morning to early evening (e.g., 10 am to 6 pm). This schedule: