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Senator Bob Corker called the Trump White House an "adult daycare," only to later choose not to seek reelection due to backlash from Trump supporters. Similarly, Jeff Flake’s anti-Trump rhetoric – warning about the dangers posed to democracy – culminated in plummeting approval ratings, forcing him to retire. John McCain’s infamous vote against Trump’s health care repeal tainted his legacy, leading Trump to mock him even posthumously.
The Cabinet Turncoats: Tillerson and Mattis
Rex Tillerson's opposition to Trump's foreign policy led to his dismissal via Twitter, while James Mattis's resignation over Syria policy resulted in Trump branding him "the world's most overrated general." Both faced substantial downfall, losing any relevant political standing.