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The story of San Francisco Plantation begins in the early 19th century, even before the house itself was built. In 1827, a free Black man named Élique Rellio began acquiring land along the east bank of the Mississippi River. He envisioned creating a thriving sugar plantation on this fertile land. By 1830, Rellio had sold the property for an astounding $100,000—a sum equivalent to approximately $3.5 million today—to Edmond Marmillion and his business partner, Eugene Lartigue.