It's going to be tough but I don't think we can do much about the CEX. They have to play by the rules but I do think that just having the option to avoid the system to an extent does help. I do hope that web3 and decentralization wins out in the end.
Oh yeah, CEXes are pretty much conquered already. But they don't settle with that. They want control over Bitcoin (in various ways), and some of its forks are even easier targets because of the centralization, Ethereum and the EVMs are next but they haven't focused on them much yet, Solana is another ideal target, with the kind of centralization and the heavy nodes it has (and I've seen it promoted by Wall Street guys, besides BTC and ETH, which is a sign), and so on.