Pain Pivot: Scientists have developed SBI-810, an experimental painkiller that delivers powerful pain relief without the side effects that make opioids so risky. While opioids flood multiple brain pathways indiscriminately, SBI-810 uses "biased agonism" to target only specific pain-relief signals while avoiding ones that cause the euphoric high linked to addiction. With over 80,000 Americans dying annually from drug overdoses (mostly opioids), this targeted approach could finally provide a much safer pain management option.
https://www.sciencedaily.com/releases/2025/05/250519131126.htm