Climate change would be one. Our fire seasons here in the western US seem to be getting longer and more intense. We just had a red flag warning in the mountains in April. It is very rare to have an April red flag fire warning here. Last fall, fires were burning close enough to Portland Or that some suburbs were put on evacuation notice.
Another possible pandemic. I wasn't overly impressed with humanities response to this last one.
And I never underestimate government or powerful people's ability to royally screw things up for us all. :)
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