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I think he means, if the interest you're paying on the mortgage is less than the interest (or profit, whatever) you're earning on the Bitcoin. So like, if your mortgage interest is 5% annually (I have no idea what interest rates on mortgages are like, I'm making up numbers), but you're earning 20% returns on investment with Bitcoin, it's a better return to HODL.
However, I'm with you and Suze Orman on the "debt is bondage" idea. I'd rather pay it off, too.

Edited to add: I think it would also make a difference on the size of the debt/investment. So even if your mortgage was 5% and Bitcoin was 20%, if you owe 100k on the house but only have 1k in Bitcoin ...(enter math here).

Yes - if yer earning 30% in a defi farm there's no point paying off a 5% mortgage!