It will have to be a protocol that is designed to use the processing power of many different computers. This is what has happened in the past with many different projects (protein folding comes to mind).
And we have to consider the compute tied to BTC, ETH, and other blockchains.
The protein folding was my though as well. I don't know how easy it is to setup though. I wonder if Leo can do it, since they want to pursue AI. They can reward LEO tokens as well.