Unlike ivermectin, which affects the nervous system and can harm other beneficial insects, nitisinone primarily targets blood-feeding pests.
This could reduce the ecological damage associated with traditional insecticides.
Next steps
The research team is now working to determine the optimal dosage of nitisinone for mosquito control in real-world settings.
A semi-field trial will provide further insights into how this drug could be incorporated into malaria prevention programs.
If successful, alternating nitisinone with ivermectin could offer a strategic approach to mosquito control, especially in regions where ivermectin resistance has become an issue.
Beyond its role in malaria prevention, increased use of nitisinone could also make it more affordable for patients who rely on it for metabolic disorders.