The company in a statement credited Han with helping Samsung become a global leader in TV business and for contributing to the company's growth as an executive during a challenging business environment.
"Our deepest condolences are with his family and loved ones during this difficult time," Samsung said.
Han, one of four executive directors on Samsung's board, had hosted the company's annual general shareholders meeting in Suwon, South Korea, just one week ago, fielding questions about the firm's poor stock performance.
The company said Jun Young-hyun— who was appointed as co-CEO in November last year— will become the sole CEO.