"Russia is proving literally every day with its cruelty that nothing has changed for them," Zelenskyy said.
He accused Moscow of wanting to "destroy and capture more as long as the world allows them to wage this war."
On Saturday, a strike on the embattled city of Pokrovsk killed a man in his 40s and wounded two others, the Donetsk governor, Vadym Filashkin, said.
Separately, four people were killed Saturday by drone attacks in the eastern Kharkiv region, one of which hit a meat processing plant, the head of its military administration, Oleg Synegubov, said.
A drone attack also killed a 74-year-old man in the southern Kherson region, the governor, Oleksandr Prokudin, said.