"After careful consideration, I have directed federal prosecutors to seek the death penalty in this case as we carry out President Trump's agenda to stop violent crime and Make America Safe Again," Bondi said.
Mangione, a 26-year-old Ivy League graduate, faces separate federal and state murder charges for the killing, which rattled the business community while galvanizing health insurance critics.
The federal charges include murder through use of a firearm, which carries the possibility of the death penalty. The state charges carry a maximum punishment of life in prison. Mangione has pleaded not guilty to a state indictment and has not entered a plea to the federal charges.
Prosecutors have said the two cases will proceed on parallel tracks, with the state case expected to go to trial first. It wasn't immediately clear if Bondi's announcement will change the order.