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NextDNS does a lot more, it has a unique list no one else has, it also uses machine learning to block threats, it also has other features not possible on a Pi-Hole

OK, I will look into it. Sounds very good and I hate a bit to run pi 24/7 :P

Another question is, they are trustworthy? I mean nobody knows what they do with data, p2p encryption or not.

It would be possible, there was be a lot of shady things in the past ( not with DNS exactly) but with VPN/ encryption services and so on.