Bioengineered heart patch integrating with damaged heart tissue to restore function, showing the future of regenerative cardiac therapy. Image by the Author
Heart damage from a heart attack has long been considered permanent, but new research is changing that. Scientists are developing bioengineered heart patches that can replace damaged tissue and help the heart work better.
The first big step came in 2017, when researchers at Duke University created a “cardiopatch” from human stem cells. These patches included heart muscle, structural, and blood vessel cells. By growing them in a special moving culture, the tissue became strong and mature. The patches could beat, conduct electrical signals, and contract like real heart tissue. Even large patches worked well, and in animal tests, they survived, connected to blood vessels, and stayed active without causing heart rhythm problems. At this stage, the patches were still thin, lacked their own blood vessels, and had not been tested in humans.
In 2021, these patches were used in a human trial . A 46-year-old woman with severe heart failure received a stem cell-derived heart patch. The patch successfully integrated with her heart, helping repair damaged tissue and improve heart function. Immune suppression was needed to prevent rejection, but this study shows that bioengineered heart patches can now move from the lab into real-world treatment. The result was published in 2025, highligting the potential to restore heart function. While more research is needed, bioengineered heart patches could one day restore lost heart function and prevent heart failure .
References:
Shadrin, I. Y., Allen, B. W., Qian, Y., Jackman, C. P., Carlson, A. L., Juhas, M., Bursac, N. (2017). Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell derived engineered heart tissues . Nature Communications 8(1) , 1825 . https://doi.org/10.1038/s41467-017-01946-x
Cyranoski, D. (2025, January 29) . Scientists develop patch to repair damaged hearts in humans. Nature. https://www.nature.com/articles/d41586-025-00273-2
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