Thanks. Apple has done this several times now with great success. As this article from 2016 shows, the switch from PowerPC to Intel went smoothly.
The key this time will be Rosetta 2 an update of the original, which allowed support for older hardware during the switch.
After turning in their ($1000 at the time) dev boxes, Apple sent developers the first Intel-based iMac in return. The new Mac mini developer kits will start shipping next week. We'll see what happens this time, but I've never been more excited for the future of Apple!