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-HOW IT ALL STARTED
The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide, particularly to China, Japan, and South Korea. Scientists are endeavoring to find antivirals specific to the virus. Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19) in China; some promising results have been achieved thus far. This article summarizes agents with potential efficacy against SARS-CoV-2.
-CURE FOUND?
As anxiety over the potential spread of the novel coronavirus has increased, so have the fake treatments and cures for COVID-19, the disease the virus causes.
This prompted the Food and Drug Administration (FDA) and Federal Trade Commission (FTC) to send warning lettersTrusted Source this week to seven companies for selling “fraudulent COVID-19 products” that claim to prevent or treat the disease.
The products cited in these warning letters include teas, essential oils, tinctures, and colloidal silver. The FDA stated that “there are currently no vaccines or drugs approved to treat or prevent COVID-19.” So really there is no cure for covid-19 yet no matter what the internet says.
-HOW CLOSE ARE WE TO FINDING TREATMENT FOR THE DREADFUL COVID-19
The COVID-19 coronavirus pandemic poses a unique challenge for healthcare providers. There are no approved treatments for this disease, nor are there any approved vaccines.
That’s put big drug companies, universities and biotech startups on the hot seat. Since the 2003 outbreak of SARS, another variety of deadly coronavirus, they’ve been researching ways to handle diseases that can be produced by this family of viruses. When a coronavirus is capable of infecting humans, it typically attacks the respiratory system, which can make them particularly deadly.
It usually takes about 10 to 15 years to develop a vaccine. The good news: leaps in technology, such as the ability to rapidly sequence virus genomes and to create vaccines out of messenger RNA, are speeding up the process of development. Developing new drug treatments can also take time – about a decade from discovery to getting on the market. But here technology also provides an advantage: new types of antiviral drugs and immunotherapy treatments, can treat a wide range of diseases. Which means that drugs already in the development pipeline or already treating diseases in patients could be useful to fight COVID-19, shortening the time it will take to make an effective medicine.
On this page, we’ll be tracking and regularly updating the development of new treatments and vaccines for COVID-19, from research to testing to commercial release.
Gilead Sciences
For the past few years, Foster City, California-based Gilead has been developing Remdesivir, an anti-viral that’s shown promising results in lab and animal studies against SARS, MERS, Ebola and other infectious diseases, including COVID-19. The company has initiated clinical trials in the U.S. and China to see if the drug can be effective against the new coronavirus, and also working with governments to provide the drug as an emergency treatment in the absence of other options.
Status: Large-scale human testing
Of note: A World Health Organization assessment from February described remdesivir as the “most promising candidate” against COVID-19.
AbbVie manufactures the co-formulation lopinavir/ritonavir, which is used to treat HIV. It’s currently collaborating with health authorities to see if it can be used as a treatment against COVID-19, based on unconfirmed reports in China that its use was helpful in combating it. It has provided the drug to several countries, including China, as an experimental option.
Status: Working with health authorities such as the CDC, WHO, and the National Institutes of Health regarding testing.
Moderna
Cambridge, MA-based biotech startup Moderna has developed a potential mRNA vaccine against COVID-19. The vaccine was developed in collaboration with scientists at the National Institute of Allergy and Infectious Diseases. The vaccine works by getting the immune system to develop antibodies against a “spike protein” found on the virus. A batch of the vaccine has been manufactured and delivered to the NIAID for a first round of testing.
Status: Phase 1 testing
Of note: The vaccine was developed, manufactured and sent out for testing just 42 days after the coronavirus DNA sequence was first published.
vaccine candidates.
Status: Investigation and development
Of note: In addition to looking at new therapies, Johnson & Johnson has sent batches of its HIV drug darunavir/cobicistat to China to test its efficacy against COVID-19.
Eli Lilly
Indiana-based pharmaceutical company Eli Lilly announced that it is partnering with Vancouver-based biotech firm AbCellera to co-develop antibody-based treatments against COVID-19. The firms have already discovered “hundreds” of antibodies that might be effective against the disease, with the next step being to screen those for the most effective treatment candidate.
Status: Screening antibody candidates to move to testing phase
Of note: “In 11 days, we’ve discovered hundreds of antibodies against the SARS-CoV-2 virus responsible for the current outbreak,” AbCellera CEO Carl Hansen said in a statement.
Pfizer
Earlier this month, Pfizer announced that it had discovered several promising antiviral molecules that stop the SARS-CoV-2 virus from reproducing in cells in the lab. The candidates are currently being screened to identify the best candidates to move into the development pipeline. The company’s Chief Science Officer, Mikael Dolsten, noted that the company might also consider exploring the combination of these molecules with antiviral treatments developed by other firms.
Status: Early development
Of note: On Friday, the company announced that part of its plan to combat COVID-19 would be sharing its expertise with smaller biotech companies and committed to using its excess manufacturing capacity to scale up any approved therapy or vaccine.
GlaxoSmithKline
GSK has previously developed a pandemic vaccine adjuvant platform, a system that helps to improve vaccines by strengthening the immune response in patients who receive it. In February, the company announced it was partnering with the Coalition for Epidemic Preparedness Innovations to use that platform to improve potential vaccines to the new coronavirus. As part of that collaboration, it signed an agreement with the University of Queensland, Australia, which is developing a potential vaccine. GSK has also partnered with Chinese pharmaceutical company Clover to use its adjuvant platform with that company’s COVID-19 vaccine candidate.
Status: Vaccines are still in early testing
Vir Biotechnology
San Francisco-based Vir Biotechnology announced March 12 that it’s going to be collaborating with BioGen to manufacture antibodies that may have potential to treat COVID-19. The company has identified antibodies from people who recovered from SARS, and is studying to see if they might be active against the new coronavirus, as the two are very similar. Vir is also working with federal agencies to advance its research against other coronaviruses.
Status: Early stage
Of note: In February, Vir announced it’s working with Chinese pharmaceutical firm WuXi Biologics on this research as well.
ALL WE CAN DO IS HOPE
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