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There is a definitely an energy transfer taking place between the observer and the observed. But, in that context, everything is information transfer in this existence. Perhaps the observation causes an energy to breakdown the wave function, or perhaps what we think we know is totally wrong, and what we expect to see manifests due to our interaction with the unknown. Basically, Schrödinger's cat comes to mind. It seems that we are affecting reality by our conscious observation.

If true, then pretty much everything we know is subject to questions of observational interaction resulting in a causal relationship as opposed to the true nature of Quantum Mechanics as we now know them.

It should, then, make you wonder how much of the scientific community's formulas also need an external variable to trace that causal interaction on a subatomic level in order to verifiably and accurately calculate the physics of the Universe. Perhaps this is the component in Unifying Theory that is missing.