My suggestion to newer people is to ignore the larger accounts. Focus the attention upon the Dolphins, Minnows, and other Red Fish. Give your upvotes to these people and comment on their stuff. The likelihood of them supporting you back is much greater.
None of the people I regularly interact with here are this stupid. But what a lot of them forget is supporting their commentators (who are practically the same people who upvote their posts) by upvoting their comments.