Sort:  

Yes and he is very good at that and it came together very well in “the shape of water” but with Frankenstein now, it is his second movie relying on a monster for an antagonist ;)

Oh.. to be honest, I don't know much of his works, that's why I checked on Wiki :D I've read a plot summary of "Shape of the water" and it doesn't look to me like the 'monster' (amphibian man) was an antagonist there? it felt like the main antagonist was one of the scientists

That’s true. But the amphibian man becomes vengeful at the end so maybe there’s no protagonists in Del Toro’s world ;) Similar plot with Frankenstein too.. if you are uninitiated to his movies I would highly recommend.