As I haven't played any of the main games I don't know many of the references in the series, but the most characteristic I saw was that they showed the S.P.E.C.I.A.L. stats system and the classic Nuka Cola.
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Oh, I'm sure most insider references went totally over my head too. There were supposed to be some hidden "easter eggs", but not only have not noticed them, but even when I read about them they didn't make any sense to me. That's what happens if one hasn't played the games. I did notice Nuka Cola though!