Part 3/13:
The Science of Ketosis and Its Broader Implications
D’Agostino elaborates on ketosis’s multifaceted benefits, such as its role in managing epilepsy (via the Charlie Foundation), reducing oxygen toxicity seizures in divers, and neuroprotective effects. He highlights how ketosis changes the neuropharmacology of the brain, suppresses appetite, and enhances neuroresilience, making it valuable for both military personnel and civilians.
He cites animal studies and human experiments showing that nutritional ketosis can modulate inflammation, oxidative stress, and gene expression pathways linked to aging. For example, ketone bodies like beta-hydroxybutyrate function as signaling molecules, influencing histone modification and gene pathways that confer disease resistance and longevity.