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A critical feature of Ibogain’s action lies in its influence on dopamine, the neurotransmitter linked to the brain's reward system. In addicted individuals—whether humans or animal models—dopamine responses tend to fluctuate wildly, reinforcing addictive behaviors. Studies have demonstrated that administering Ibogain helps normalize this dopamine response, stabilizing the brain's reward circuitry.
In experimental settings, such as with rats, these fluctuations are significantly flattened after Ibogain treatment. This normalization could underlie the reduction in cravings and the potential for sustained recovery, marking a promising avenue for future addiction therapies.