purely the lack of oxygen? So an anesthesiologist, actually the same one who's going to do the lower dose opioids question, he did a whole series of experiments with rodents looking at what fentanyl does to the hippocampus. And he kept them intubated. So it wasn't a lack of oxygen. And they had this same damage to the hippocampus. So then you have the animal evidence really backing up what is seen in these amnestic patients. So that's enough of a basis to say, well, is this really relevant to humans? And is our opioids at lower doses and less potent opioids, are they not like removing the bartenders from the bar, but just giving them some drinks so that they're not doing their job as well, and then interfering in the function of the hippocampus. So do we know anything about how opioids interfere with inhibitory neurons? Yes. So they do the opposite of what normally you would think, oh, you put a drug in and it turns on a neuron. Well, it doesn't. It turns these guys off completely. So (33/37)
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