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RE: Sickle cell anaemia: pathogenesis, triggers, clinical features and treatment ...

in StemSociallast month

I feel like Val has crept into my reading a lot lately.

Do you think that maybe something like CRISPR could be used to modify the sequence for future erythrocyte production via hematopoietic stem cells? I wonder what the underlying sequence looks like and if it is heavily replicated in the genome.

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I recently saw this new technological advancement and read about it... It really looks promising.
I really don't know if it can because we haven't even used it here for the first time so I haven't had a first-hand experience but it looks quite promising.

I'm not sure it's been used in humans in general. The problem would be reside in repeat sequences. You have to cut the nucleotides of interest out and then it gets "repaired" with the dna you're trying to insert.

Yes, I think I read about that too...
Well, we just have to wait for it's first human use and then look out for the possible complications it might have... Once the benefits exceeds the disadvantages, I think we're good to go

I think we're quite a ways away from that. Many problems from sickle cell are secondary to the morphology of the cell right? I'd say it'd be really hard to fix this condition without genetic modification.

Absolutely correct.... All their problems are from the defective or rather point mutation on the chromosome