Biosynthesis of Vitamin C
Ascorbic Acid Generation
Aldonolactone Oxidoreductase
Vanillyl Alcohol Oxidase
Gulono Lactone Oxidas
GULO Gene Activation
Lactone Glucose
Tryptophan
Tetrahydrobiopterin
Serotonin Melatonin
Inositol Glycine
Thiosugar
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Structure, mechanism, and evolution of the last step in vitamin C biosynthesis
https://www.nature.com/articles/s41467-024-48410-1
Advances in Novel Animal Vitamin C Biosynthesis Pathways and the Role of Prokaryote-Based Inferences to Understand Their Origin
https://pmc.ncbi.nlm.nih.gov/articles/PMC9602106/
Vitamin C Supplementation Improves Chronic Kidney Disease
https://orthomolecular.org/resources/omns/v15n18.shtml
Vitamin C and alcohol: a call to action
https://pmc.ncbi.nlm.nih.gov/articles/PMC7678474/
Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress
https://pmc.ncbi.nlm.nih.gov/articles/PMC6045543/
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VC is also a cofactor in the conversion of violaxanthin to zeaxanthin, catalyzed by violaxanthin de-epoxidase during the xanthophyll cycle, contributing to the protection of the photosynthetic apparatus from photodamage in excess light conditions.
Hair loss and poor haircoat are reported; vitamin C is important in the disulfide bonding of hair.
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finding clues regarding a connection between genetic errors, metabolic pathway malfunction & how it appears directly connected to the reason humans do not make vitamin C like most other plants & animals.
its all interconnected in one single genetic malfunction to a single enzyme reaction.
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Chromatin
https://en.m.wikipedia.org/wiki/Chromatin
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Vanillyl Alcohol Oxidase (VAO) is a fungal flavoenzyme, particularly found in lignin-degrading ascomycetes, that catalyzes the oxidation of various para-substituted phenols. It belongs to a family of oxidoreductases sharing a conserved FAD-binding domain, with the enzyme itself named for its ability to oxidize vanillyl alcohol to vanillin.
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Flavoenzymes
Biocatalytic Applications
Flavoenzymes are colourful oxidoreductases, some flavoenzymes the isoalloxazine ring of the flavin is covalently linked to a His, Cys or Tyr residue of the polypeptide chain, typically contain either a FMN or a FAD cofactor,
Oxidative stress and ion channels in neurodegenerative diseases
https://pmc.ncbi.nlm.nih.gov/articles/PMC10859863/
glutathione, catalase, and superoxide dismutase
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Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
https://pmc.ncbi.nlm.nih.gov/articles/PMC9598715/
NFκB/TNFα pathway