PI3K/AKT/mTOR
PI3K-mTOR Decoupling
SIN3-HDAC Inhibition
α-ketoglutarate (a-KG)
Chromatin Remodeling
Transcriptional Derepression
Histone Deacetylase HDAC
Chloride Channel Activation
PI3K/mTOR INHIBITION MARKEDLY POTENTIATES HDAC INHIBITOR ACTIVITY IN NHL CELLS THROUGH BIM- and MCL-1-DEPENDENT MECHANISMS
https://pmc.ncbi.nlm.nih.gov/articles/PMC4166554/
https://www.airmidbiogenetics.com/gene-reprogramming-paper
Ascorbate also directly modulates the PI3K/AKT/mTOR signaling pathway
Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut—A Pilot Study
https://pmc.ncbi.nlm.nih.gov/articles/PMC8389205/
Chemical Stability of Ascorbic Acid Integrated into Commercial Products: A Review on Bioactivity and Delivery Technology
https://pmc.ncbi.nlm.nih.gov/articles/PMC8773188/
Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin
https://www.sciencedirect.com/science/article/pii/S0022202X1532491X
Biological and cellular effects when a fatty acid/DMSO mixture is introduced into a biological system:
Changes in lipid metabolism:Decreases fat accumulation: Studies on liver cells have shown that DMSO treatment can decrease overall lipid accumulation and increase fatty acid oxidation.
Induces autophagy: In a dose-dependent manner, DMSO can activate autophagy, a cellular process that degrades lipids. This mechanism contributes to the reduction of lipid content in cells exposed to fatty acids.
B vitamins and lipid synthesis
Primarily B-family, serve as crucial cofactors for enzymes involved in the synthesis of lipids such as fatty acids, triglycerides, and cholesterol.