3D model of Carbidopa
Hi,
I made this account to share cool information about some of the chemicals we use, and also teach people a few things about chemistry. I have always been fascinated by the pharmacology of Carbidopa, so it is my first entry! I hope you all enjoy it, and you can expect a post every week on an interesting chemical. I am open to suggestions! Please do not hesitate to ask questions too, I have a lot of background in chemistry and like explaining things in less convoluted ways!
Chemical Of The Week 1. Carbidopa
Chemical Identifier #. 34359
Empirical Formula: C10H14N2O4
Molecular Weight: 226.23
Synonyms: Lodosin, Lodosyn, Methyldopahydrazine, MK 485
Carbidopa is a drug used in the treatment of Parkinsons, usually in conjunction with Levodopa (aka L- Dopa). It functions by blocking the conversion of L-Dopa to Dopamine by Dopa decarboxylase. This may seem odd because you want more Dopamine in the brain. However it cannot cross the blood brain barrier, but L-dopa can, where it then is converted to Dopamine in the Substantia Nigra.
George Cotzias, a Greek-American scientist, is credited with the discovery of the ability of Carbidopas to increase the effectiveness of Parkinsons treatment with Levodopa. He also made the critical observation that Parkinsons symptoms decreased when Levodopa was administrated in increasing dosages over time.
Carbidopa became commercially available in 1975.
Line drawing structure of Carbidopa
References:
https://pubchem.ncbi.nlm.nih.gov/compound/carbidopa
https://www.ncbi.nlm.nih.gov/pubmed/9633679
https://medlineplus.gov/druginfo/meds/a601068.html
https://en.wikipedia.org/wiki/Carbidopa
George Cotzias
https://en.wikipedia.org/wiki/George_Cotzias
Chemistry question:
Can acyl azides be prepared from carboxylic acids without activation of the carboxyl group (acyl chloride, anhydride, carbodiimide, active ester, etc.)? I’m preparing a precursor for Curtius rearrangement and hydrolysis to prepare the amine with one less C. (No other sensitive functional groups are present). Have you ever heard of cesium fluoride being used in this context? I know the best approach is to use DPPA, but interested in other options.
Boy, it has been a long while since I have done any synthesis. Let me get back to you, I wanna take a peak at the Beilstein manuals. They must be online somewhere.
Do you have access to a university or institutional library account? I would like some PDFs of some of my publications for my records.
I wish. Sounds like you need to friend a student at a university.
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Chemistry question:
Can acyl azides be prepared from carboxylic acids without activation of the carboxyl group (acyl chloride, anhydride, carbodiimide, active ester, etc.)? I’m preparing a precursor for Curtius rearrangement and hydrolysis to prepare the amine with one less C. (No other sensitive functional groups are present). Have you ever heard of cesium fluoride being used in this context? I know the best approach is to use DPPA, but interested in other options.
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Oh snd My friend @medro-Martin Will be interested
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Dope imma follow you, this will be interesting and welcome to steemit.
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Thank you! I contemplating next weeks post. Think I will have a very interesting one...........
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Hi and welcome here! When I started on steemit, my biggest problem was to find interesting people to interact with. So, to help newcomers getting started I created a directory with other interesting and or talented steemians to follow or interact with. Feel free to check it out at https://www.steemiandir.com I am sure it will help you find like-minded people. Enjoy your stay here and do not hesitate to contact me if you have any questions!
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